Magnesium Homeostasis in CKD

Glucose and Insulin Homeostasis in Ckd

S145 Cardiovascular disease (CVD) is the main cause of death in peritoneal dialysis (PD) patients, a situation that can be explained by a combination of traditional and nontraditional risk factors for CVD in these patients. Glucose and insulin homeostasis are altered in chronic kidney disease (CKD) patients even in the early stages of CKD, leading to insulin resistance by various pathways. Seve...

Magnesium homeostasis in mammalian cells.

Mammalian cells tightly regulate cellular Mg2+ content despite undergoing a variety of hormonal and metabolic stimulatory conditions. Evidence from several laboratories indicates that stimulatory conditions that increase cellular cAMP level result in a major mobilization of Mg2+ from cells and tissues into the bloodstream. Conversely, hormones or agents that decrease cAMP level or activate prot...

Calcium and Magnesium Homeostasis

Mysteries of magnesium homeostasis.

In this issue of Circulation Research, Romani and colleagues1 report that insulin stimulates uptake of ionized magnesium (Mg) into heart. This study is the latest in a series by Romani, Scarpa, and colleagues regarding hormoneregulated Mg fluxes in heart and liver (References 1 and 2 and references therein). Over the past several decades, we have begun to uncover the mysteries of how cytosolic ...

Magnesium homeostasis and aging.

Aging is very often associated with magnesium (Mg) deficit. Total plasma magnesium concentrations are remarkably constant in healthy subjects throughout life, while total body Mg and Mg in the intracellular compartment tend to decrease with age. Dietary Mg deficiencies are common in the elderly population. Other frequent causes of Mg deficits in the elderly include reduced Mg intestinal absorpt...